Prescription Only
Estriol Cream
Prescription treatment used to relieve vaginal dryness, soreness, and discomfort associated with low oestrogen levels.
Applied locally to the vagina, with minimal absorption into the bloodstream.
Prescription-only • Supplied only if clinically appropriate
Select Supply Option
1 Month Supply
1x Oestrogel Pump + 30x Utrogestan 100mg
£45.00
3 Month Supply
Most popular clinical regimen
£120.00
- UK Pharmacy
- GPhC Registered
- Discreet Delivery
Overview
Estriol vaginal cream is a low-dose vaginal oestrogen used to treat symptoms caused by reduced oestrogen in the vaginal tissues.
It is commonly prescribed for women experiencing vaginal dryness, irritation, soreness, pain during sex, or recurrent discomfort — particularly during and after menopause.
Estriol acts locally in the vagina and is considered a suitable option for many women who do not require, or do not wish to use, systemic hormone replacement therapy.
Learn More About This Treatment
Reduced oestrogen can cause the vaginal tissues to become thinner, drier, and less elastic.
Estriol is a mild form of oestrogen that works by:
- Helping restore moisture and elasticity to vaginal tissues
- Improving comfort and reducing irritation
- Supporting healthier vaginal lining over time
Because estriol is applied directly to the vagina, only very small amounts are absorbed into the bloodstream.
Treatment Offered
Estriol 0.01% vaginal cream (dose and duration determined by clinician).
How to use
- Applied inside the vagina using an applicator
- Usually used daily at first, then reduced to a maintenance schedule
What to expect
- Some improvement may be noticed within a few weeks
- Full benefit can take several weeks of regular use
- Maintenance use may be recommended to keep symptoms controlled
Like all medicines, estriol vaginal cream can cause side effects, although not everyone experiences them.
Possible side effects include:
- Local irritation or itching
- Vaginal discharge
- Mild spotting, particularly when starting treatment
Important Information:
- Not suitable for everyone
- Certain medical conditions may mean vaginal oestrogen is not recommended
- Suitability is assessed during your consultation by a UK-registered clinician
For full prescribing and safety information, please read the official patient information leaflet:
FAQs
Do I need to take HRT to use estriol cream?
No. Vaginal estriol can be used on its own without systemic HRT.
Is vaginal oestrogen safe?
For many women, local vaginal oestrogen is considered low risk. A clinician will assess suitability.
How long can I use estriol cream for?
Some women use it long-term. Ongoing use is reviewed as part of clinical care.
Will it help with pain during sex?
It may help by improving vaginal moisture and tissue health, but results vary.